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. Author manuscript; available in PMC: 2018 May 29.

Published in final edited form as: J Pharm Biomed Anal. 2016 Mar 14;127:3–8. doi: 10.1016/j.jpba.2016.03.030

Plasma pro le of ketamine, norketamine and (2S,6S;2R,6R) HNK and 4(2S,6R;2R,6S)-HNK obtained from Wistar rats receiving a single i.p. injection (A) and a single i.p. injection of 40 mg/kg (R,S)-Ket once per day for 14 days (B). Each data point represents the mean ± SD for n=3 rats. Time points were collected through 72 h.

Plasma pro le of ketamine, norketamine and (2S,6S;2R,6R) HNK and 4(2S,6R;2R,6S)-HNK obtained from Wistar rats receiving a single i.p. injection (A) and a single i.p. injection of 40 mg/kg (R,S)-Ket once per day for 14 days (B). Each data point represents the mean ± SD for n=3 rats. Time points were collected through 72 h.