Table 2.
Comparison of the plasma concentrations of (R,S)-Ket and major metabolites at 30 min after the intraperitioneal administration of (R,S)-Ket and their elimination half-lives (t1/2) in Wistar rats receiving a single administration of (R,S)-Ket (Acute Arm) and after receving a single injection of (R,S)-Ket for 14 days (Chronic Arm).
| (R,S)-Ket | (R,S)-norKet | (2S,6S,2R,6R)-HNK | (2S,6R,2R,6S)-HNK | (2S,4R,2R,4S)-HNK | |
|---|---|---|---|---|---|
| t1/2 (hr) | |||||
| Acute Arm | 10.2 | 6.2 | 13.2 | ND | ND |
| Chronic Arm | 2.8 | 4.4 | 11.1 | 1.3 | 5.0 |
| Ratio (A/C) | 4.4 | 1.4 | 1.2 | - | - |
| Plasma (ng/ml) | |||||
| Acute Arm | 2780 | 2128 | 4327 | 172 | 218 |
| Chronic Arm (40 min) | 2598 | 1336 | 6146 | 780 | 378 |
| Ratio (C/A) | 0.93 | 0.62 | 1.42 | 4.53 | 1.73 |