Figure 3.

Lesion ratings. Patient lesion ratings were conducted by three independent raters and involved determination for each slice whether a lesion was present in ventral, dorsal, left lateral, and/or right lateral column of the spinal cord white matter. Final consensus ratings were determined and are depicted for each subject. Example slices, which were rated as containing a lesion, are provided. The straightened spinal cord and representative cervical slice images to the right were adapted from recently developed spinal cord templates included in the Spinal Cord Toolbox software package (Fonov et al., 2014; De Leener et al., 2017, 2018).