Table 3.
Clinical characteristics and vitamin D status of pregnant women with IBD.
| Crohn’s disease | Ulcerative colitis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vitamin D sufficient | Vitamin D insufficient | Vitamin D sufficient | Vitamin D insufficient | |||||||
| n | % [95%CI] | n | % [95%CI] | p | n | % [95%CI] | n | % [95%CI] | p | |
| Severity | ||||||||||
| Remission [CD:HBI <5; UC:SCCAI ≤2] | 28 | 54.8 [40.0 to 67.2] | 24 | 46.2 [32.8 to 60.1] | - | 13 | 39.4 [23.8 to 57.5] | 20 | 60.6 [42.5 to 76.2] | - |
| Relapse [CD:HBI ≥5; UC:SCCAI >2] |
n<5 | 7 | 77.8 [39.0 to 95.0] | 0.08 | n<5 | 5 | 62.5 [25.6 to 89.0] | 0.92 | ||
| Location | ||||||||||
| Ileal | 8 | 42.1 [21.9 to 65.4] | 11 | 57.9 [34.6 to 78.1] | - | N/A | N/A | |||
| Colonic | 8 | 57.1 [30.3 to 80.4] | 6 | 42.9 [19.6 to 69.7] | 0.39 | N/A | N/A | |||
| Ileocolonic | 14 | 50.0 [31.6 to 68.4] | 14 | 50.0 [31.6 to 68.4] | 0.60 | N/A | N/A | |||
| Behavioura | ||||||||||
| B1 | 21 | 55.3 [38.9 to 70.5] | 17 | 44.7 [29.5 to 61.1] | - | N/A | N/A | |||
| B2 | n<5 | 6 | 60.0 [27.8 to 85.4] | 0.39 | N/A | N/A | ||||
| B3 | 5 | 38.5 [16.0 to 67.2] | 8 | 61.5 [32.8 to 84.0] | 0.30 | N/A | N/A | |||
| Perianal | ||||||||||
| No | 20 | 54.1 [37.6 to 69.7] | 17 | 45.9 [30.3 to 62.4] | - | N/A | N/A | |||
| Yes | 8 | 38.1 [19.7 to 60.7] | 13 | 61.9 [39.3 to 80.3] | 0.24 | N/A | N/A | |||
| Extent | ||||||||||
| Ulcerative proctitis | N/A | N/A | n<5 | n<5 | - | |||||
| Left sided UC | N/A | N/A | 5 | 31.3 [12.8 to 58.4] | 11 | 68.8 [41.6 to 87.2] | 0.81 | |||
| Extensive UC | N/A | N/A | 10 | 47.6 [26.9 to 69.2] | 11 | 52.4 [30.8 to 73.1] | 0.40 | |||
| Duration | ||||||||||
| <10 years | 19 | 63.3 [44.4 to 78.9] | 11 | 36.7 [21.1 to 55.6] | - | 12 | 38.7 [22.8 to 57.4] | 19 | 61.3 [42.6 to 77.2] | - |
| ≥10 years | 11 | 35.5 [20.4 to 54.1] | 20 | 64.5 [45.9 to 79.6] | 0.03 | n<5 | 6 | 60.0 [27.5 to 85.6] | 0.94 | |
| Medications | ||||||||||
| No IBD therapies | 6 | 46.2 [19.5 to 75.2] | 7 | 53.8 [24.8 to 80.5] | - | n<5 | n<5 | - | ||
| Non-biologic therapy | 10 | 66.7 [37,2 to 87.1] | 5 | 33.3 [12.9 to 62.8] | 0.27 | 5 | 25.0 [9.9 to 50.3] | 15 | 75.0 [49.7 to 90.1] | 1.00 |
| Biologic therapy | 12 | 38.7 [22.7 to 57.6] | 19 | 61.3 [42.4 to 77.3] | 0.65 | 7 | 58.3 [26.7 to 84.3] | 5 | 41.7 [15.7 to 73.3] | 0.620 |
IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease; HBI, HarveyBradshaw Index; SCCAI, Simple Clinical Colitis Activity Index.
aB1: non-stricturing, non-penetrating; B2: stricturing; B3: penetrating.