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. 2018 Apr 19;39(6):767–777. doi: 10.1093/carcin/bgy034

Figure 2.

Figure 2.

OPCs and GSE inhibit cancer cell migration. (A) Left: Representative images of cells that migrated through the permeable membrane in a transwell migration plate, 6 h after treatment with OPCs or GSE at 100 ng/ul. Right: Count of cells that migrated through the membrane, shown as an average of triplicates. (B) Left: Representative images of monolayer of SW480 and HCT116 cells treated with 100 ng/ul OPCs or GSE, 6 h post scratch. Right: Quantification of migrated cells from triplicate treatments. (C) mRNA expression of EMT markers Zeb1, Zeb2, Snai1 and E-Cad in OPCs/GSE-treated HCT116 and SW480 cells, shown as fold change with respect to control cells treated with vehicle (DMSO). (D) mRNA expression of genes associated with cancer cell migration. *P < 0.05, **P < 0.01, ***P < 0.001 compared with control treatments.