Figure 5.

OPCs suppress growth of organoids derived from human colorectal tumors. (A) Schematic protocol of primary culture of tumors derived from patients. (B) Representative images showing tumor organoid cultures derived from a colorectal cancer patient, treated with 0–200 µg/ml of OPCs and GSE. (C) Bar graph showing a decrease in spheroid count with OPCs or GSE treatments in two separate patient-derived organoids. (D) mRNA expression levels of genes in patient-derived organoids treated with OPCs and GSE, normalized to control (DMSO treated) organoids. *P < 0.05, **P < 0.01, ***P < 0.001.