Table 2. Published WHO recommendations for antibiotic therapy for children >2 years presenting with suspected cholera.
Condition | ‘Antibiotic of choice’ | Alternative | In addition |
---|---|---|---|
WHO Pocketbook Recommendations Cholera with severe dehydration [12,20] | Tetracycline 12.5 mg/kg qid for 3 days | Erythromycin 12.5 mg/kg qid for 3 days | Zinc supplementation |
or | or | 20 mg/kg for 10–14 days as soon as vomiting has ceased | |
Doxycycline (dosage not listed) | Chloramphenicol 20 mg/kg IM qid for 3 days | ||
or | |||
Cotrimoxazole (dosage not listed) | |||
WHO 2010 PAHO Recommendations (Haiti outbreak) | Option 1 | Option 2 | |
Children over 3 years who can swallow tablets | Erythromycin 12.5 mg/kg/6 h for 3 days | Ciprofloxacin, suspension or tablets 20 mg/kg in a single dose | |
or | or | ||
Azithromycin, 20 mg/kg in a single dose not exceeding 1 g | doxycycline suspension or tablets 2–4 mg/kg PO in single dose | ||
Children under 3 years, or infants who cannot swallow tablets | Erythromycin, suspension, | Ciprofloxacin suspension 20 mg/kg, in a single dose | |
12.5 mg/kg/6 h for 3 days | |||
or | or | ||
Azithromycin suspension 20 mg/kg in a single dose | Doxycycline syrup 2–4 mg/kg PO in a single dose |
Note: IM, intramuscular; qid, four times daily.