Fig. 1.

Toppar’s main interface. The filtering panel (A) allows the user to navigate and view the data by selecting available sub-categories. From the genome view (B), one navigates to a specific genomic locus by selecting it on the plot. This refocuses the display to the region (chromosome) view (C). Beyond a certain level of zoom-in the appearance of the plotted dots that indicate association results changes from small filled circles (D) to larger open circles, indicating they have become interactive and that test statistic associated with the point/test are displayed on mouseover. An interactive point becomes red when selected, with the variant name displayed above it, and the LD pattern of all data points relative to the one selected can be displayed (D). At further zoom-in, exonic regions are also displayed for each gene (E). GWAS catalog SNPs can be added and colored based on traits of interest and hovering over a GWAS variant displays its rs identifier, P-value and associated disease trait and pubmed id, while selecting the variant takes the user to the referenced pubmed article (E). Multiple traits can be viewed simultaneously (F), where each trait appears on a separate but synchronized plot: zooming in on one plot automatically refocuses the other plots