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. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2018 Apr 24;349:29–38. doi: 10.1016/j.taap.2018.04.022

Figure 5.

Figure 5

Cytotoxicity of UA in CHO AA8 (●), UV5 (■), and 5T4-12 (▲) cells after 24 hr (A) and 48 hr (B). Cells were treated and assayed for 7-day colony formation as described in the text. UA-treated corrected mutant cells, 5T4-12, showed a significant increase in survival compared to the repair-deficient UV5 cells after 24 hr. Data represents mean ± SEM for n = 8 – 11 independent experiments. P values were considered to be statistically significant as indicated with ** (p < 0.01) and *** (p < 0.001) compared to untreated cells for the respective cell line after 24 or 48 hr; a (p < 0.05) and b (p < 0.001) are the p values of UA treated UV5 and 5T4-12 cells compared to cells treated with equivalent UA doses in the parental AA8 cell line after 48 hr; d (p < 0.001) is the p value of UA treated UV5 cells compared to cells treated with equivalent UA doses in the repair proficient 5T4-12 cell line after 48 hr.