Skip to main content
. Author manuscript; available in PMC: 2019 Jun 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2018 Apr 24;349:29–38. doi: 10.1016/j.taap.2018.04.022

Table 1.

Mutant Chinese hamster ovary cell lines. The repair deficient cell lines that prevent specific DNA damage repair mechanisms. As a result, the cell lines are sensitive to specific types of DNA lesions.

Cell lines: Gene Deficiency: Protein Function: Sensitivity: References:
AA8 (parental) – – – –
EM9 XRCC1 Acts as scaffolding protein, ligation, gap filling (BER) Single strand breaks (Thompson 1990)
V3.3 XRCC7 Non-homologous end joining repair (NHEJ); reduced expression of the DNA-PKCS Double strand breaks (Rothkamm 2003)
UV5 ERCC2 (XPD) NER Bulky adducts (Cullinane 1997)