FIG. 7.

Traumatic brain injury (TBI)-induced hippocampal neuronal death is not prevented by intranasal administration of nicotinamide (Nicot). (A) Confocal fluorescence images show neuron death in the hippocampal dentate gyrus (DG), CA1, and CA3 areas at 24 h after TBI. A significant number of Fluoro-Jade B (FJB)-positive neurons was seen in saline-treated rats after TBI. The number of FJB-positive neurons was not reduced by intranasal administration of nicotinamide (scale bar=50 μm). (B) Bar graph shows the quantified neuronal degeneration in the hippocampus. Data are mean±standard error of the mean (n=6 for each group; *p<0.05 compared with the saline-treated group). Color image is available online at www.liebertonline.com/neu