Table 1.
V3 loop | gp120 | nef | |||||
---|---|---|---|---|---|---|---|
Tissue being compared to liver | HIVams198 | DY | AZ | AM | DY | AZ | AM |
Basal ganglia | — | 0.0001 | — | — | 0.0002 | — | — |
Bone marrow | 0.0002 | — | — | — | — | — | — |
Brain (unspecified) | 0.0001 | — | — | — | — | — | — |
CSF | 0.0001 | — | — | — | — | — | — |
Diaphragm | — | — | — | 0.0062 | — | — | 0.0001 |
Frontal cortex | — | — | 0.0001 | — | — | 0.0001 | — |
Frontal lobe GM | — | 0.0001 | — | — | 0.0002 | — | — |
Frontal lobe WM | — | 0.0001 | — | — | 0.0001 | — | — |
Kidney | 0.0014 | — | — | 0.0001 | — | — | 0.0091 |
Lung | 0.0001 | — | — | — | — | — | — |
Lymph node | 0.0002 | 0.0002 | 0.0001 | — | NS | 0.0001 | — |
Left lymph node | — | — | — | 0.0001 | — | — | 0.0108 |
Right lymph node | — | — | — | NS | — | — | NS |
Liver tumor 1 | — | — | — | 0.0001 | — | — | 0.0027 |
Liver tumor 2 | — | — | — | 0.0001 | — | — | 0.0009 |
Meninges | — | 0.0001 | 0.0001 | — | 0.0010 | 0.0001 | — |
PBMC | 0.0050 | — | — | — | — | — | — |
Prostate | — | — | — | NS | — | — | 0.0011 |
Spleen | 0.0017 | 0.0001 | 0.0012 | 0.0071 | 0.0046 | 0.0042 | NS |
Stomach lymphoma | — | — | — | 0.0001 | — | — | NS |
Temporal cortex | — | 0.0001 | — | — | 0.0001 | — | — |
Sequence data for patient HIVams198 were originally reported by Van't Wout et al.19 Sequence data for patients AM, AZ, and DY were originally reported in Lamers et al.18
CSF, cerebrospinal fluid; PBMC, primary blood mononuclear cells; GM, gray matter; WM, white matter; NS, not significant; dash, no data available; p-values<0.05 were considered statistically significant.