Table 1.

Mantel's Test for Compartmentalization of V3 Loop, gp120, and nef Variants Compared to the Liver

	V3 loop	gp120			nef
Tissue being compared to liver	HIVams198	DY	AZ	AM	DY	AZ	AM
Basal ganglia	—	0.0001	—	—	0.0002	—	—
Bone marrow	0.0002	—	—	—	—	—	—
Brain (unspecified)	0.0001	—	—	—	—	—	—
CSF	0.0001	—	—	—	—	—	—
Diaphragm	—	—	—	0.0062	—	—	0.0001
Frontal cortex	—	—	0.0001	—	—	0.0001	—
Frontal lobe GM	—	0.0001	—	—	0.0002	—	—
Frontal lobe WM	—	0.0001	—	—	0.0001	—	—
Kidney	0.0014	—	—	0.0001	—	—	0.0091
Lung	0.0001	—	—	—	—	—	—
Lymph node	0.0002	0.0002	0.0001	—	NS	0.0001	—
Left lymph node	—	—	—	0.0001	—	—	0.0108
Right lymph node	—	—	—	NS	—	—	NS
Liver tumor 1	—	—	—	0.0001	—	—	0.0027
Liver tumor 2	—	—	—	0.0001	—	—	0.0009
Meninges	—	0.0001	0.0001	—	0.0010	0.0001	—
PBMC	0.0050	—	—	—	—	—	—
Prostate	—	—	—	NS	—	—	0.0011
Spleen	0.0017	0.0001	0.0012	0.0071	0.0046	0.0042	NS
Stomach lymphoma	—	—	—	0.0001	—	—	NS
Temporal cortex	—	0.0001	—	—	0.0001	—	—

Sequence data for patient HIV_ams198 were originally reported by Van't Wout et al.¹⁹ Sequence data for patients AM, AZ, and DY were originally reported in Lamers et al.¹⁸

CSF, cerebrospinal fluid; PBMC, primary blood mononuclear cells; GM, gray matter; WM, white matter; NS, not significant; dash, no data available; p-values<0.05 were considered statistically significant.