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Locomotor bursts are inhibited by SK activators and restored by SK blockers. The application of the SK activator (CyPPA) inhibits the episodic alternating bursting activity in a dose-dependent manner. After the bursting has completely ceased, the addition of the SK blocker, apamin, restores the rhythmic alternating activity. The insets show, on a different time scale, representative alternating bursts from two different episodes of activity.
