FIG 4.

Sequential antibody responses to different ZIKV or DENV proteins in ZIKV or DENV subjects. Preinfection, recent-, and convalescent-phase sera from ZIKV (A) or DENV (B) IgM-positive subjects were subjected to Western blot analysis using lysates derived from ZIKV- or DENV-infected Vero cells. Arrowheads indicate PrM, E, and NS1 proteins recognized. Molecular size marker units are kilodaltons. Dates are given in month/year format. Lysates include ZIKV African strain (unpublished), DENV1 Hawaii strain (D1), DENV2 NGC strain (D2), DENV3 H87 strain (D3), and DENV4 H241 strain (D4). Months PI, months postinfection. ZV/DV IgM, results for ZIKV (ZV) or DENV (DV) IgM serology expressed as positive (+) or negative (−).