FIG 8.

Impact of prior flavivirus infection on the ZIKV or DENV T cell response. Comparison of recent (A)- and convalescent (B)-phase IFN-γ⁺ ZIKV NS3 protease (black shaded bars) and helicase (black unshaded bars) and TNF-α⁺ ZIKV NS3 protease (gray shaded bars) and helicase (gray unshaded bars) T cell responses from presumed primary ZIKV-infected and flavivirus preimmune groups of the ZIKV subjects. Comparison of recent (C)- and convalescent (D)-phase IFN-γ⁺ DENV NS3 protease (black shaded bars) and helicase (black unshaded bars) and TNF-α⁺ DENV NS3 protease (gray shaded bars) and helicase (gray unshaded bars) T cell responses from presumed primary DENV-infected and flavivirus preimmune groups of the DENV subjects. Magnitude of response for each group is expressed as geometric positive means ± standard deviations, and statistical analyses were performed with Mann-Whitney U test. *, P < 0.05.