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. 2018 Mar 14;92(7):e02209-17. doi: 10.1128/JVI.02209-17

FIG 4.

FIG 4

Virus RNA copy numbers in Marc-145 cells and PAMs at different time points after infection with each mutant virus. (A and C) RNA copies of mutant viruses based on HuN4 (rHuN4-S519T, rHuN4-T544A, and rHuN4-S519T-T544A) (A) and CH-1a (rCH-1a-T519S, rCH-1a-A544T, and rCH-1a-T519S-A554T) (C) in Marc-145 cells relative to their parental viruses. (B and D) Viral copy numbers of mutant viruses based on HuN4 (B) and CH-1a (D) in PAM cells. The data are presented as means ± standard deviations from the results three independent experiments. δ, significant difference between rHuN4 and rHuN4-S519T or between rCH-1a and rCH-1a-T519S (δ, P < 0.05; δδ, P < 0.01); *, significant difference between rHuN4 and rHuN4-T544A or between rCH-1a and rCH-1a-A544T (*, P < 0.05; **, P < 0.01); #, significant difference between rHuN4 and rHuN4-S519T-T544A or between rCH-1a and rCH-1a-T519S-A544T (#, P < 0.05; ##, P < 0.01).