FIG 10.
Structural basis of HIV-1 resistance to SC29EK. (A) Gln-39 and Asn-43 are involved in an extensive hydrogen bond network formed by a cluster of residues and two water molecules (stick model), which mediate the complicated interactions between SC29EK and the N36 trimer. Dashed lines indicate the hydrogen bonds. (B) Gln-40 is a key member of a remarkable glutamine-rich polar layer of the 6-HB. Dashed lines indicate the hydrogen bonds. (C) The position and conformation of Glu-49 are shown in a stick model.