TABLE 2.
Cohort of four Indian-origin rhesus macaques infected by repeated low-dose exposure to uncloned SIVmac251
| Animal no. | Animal ID | Viral load peak (copies/ml) | Viral set point | MHC-I genotype | TRIM5 genotype | Binding antibodyb | Neutralization of TCLA SIVmac251b | CD20+ B cellsc |
|---|---|---|---|---|---|---|---|---|
| RP1 | Mm 156-10 | 2.8 × 108 | High (>1 × 108) | −a | TFP/CypA | − | − | + |
| SP1 | Mm 174-08 | 5.5 × 106 | Low (<1 × 105) | A*08 | TFP/TFP | + | + | + |
| TP1 | Mm 10-10 | 2.3 × 108 | Typical (1 × 105–3 × 106) | A*08 | TFP/Q | + | + | + |
| TP2 | Mm 198-08 | 1.8 × 108 | Typical (1 × 105–3 × 106) | A*08 | TFP/Q | + | + | + |
a
−, animal was negative for all nine MHC class I alleles tested.
b
−, response was low/not detected. +, response was detected.
c
+, CD20+ B cells were detected.