TABLE 1.
K8-associated proteins identified by mass spectrometry
| Accession no.a | Gene | Description | Size (amino acids) | No. of peptidesb | Score |
|---|---|---|---|---|---|
| gi:19923466 | SRRM2 | Splicing coactivator subunit SRm300 | 2,752 | 17 | 15 |
| gi:21655146 | EIF4GI | Eukaryotic translation initiation factor 4 gamma 1 | 1,600 | 10 | 8.62 |
| gi:12667788 | MYH9 | Myosin-9 | 1,960 | 7 | 6.19 |
| gi:28174906 | VIRMA | Vir-like M6A methyltransferase associated | 1,198 | 2 | 1.74 |
| gi:37589132 | EPRS | Glutamyl-prolyl-tRNA synthetase | 869 | 3 | 2.69 |
| gi:100913206 | DHX9 | DExH-box helicase 9 | 1,270 | 22 | 19.6 |
| gi:4033735 | SAP155 | Spliceosome-associated protein 155 | 1,304 | 19 | 16.8 |
| gi:3882183 | LARP1 | La ribonucleoprotein domain family member 1 | 1,096 | 11 | 9.93 |
| gi:39777586 | DEAH 57 | DExH box helicase 57 | 1,386 | 7 | 6.14 |
| gi:15215317 | RRP12 | rRNA processing 12 homolog | 1,297 | 5 | 4.14 |
| gi:27882034 | DHX8 | DEAH box helicase 8 | 1,214 | 3 | 2.69 |
| gi:1575536 | RENT1 | Regulator of nonsense transcript stability | 1,118 | 18 | 15.8 |
| gi:40254861 | UBAP2L | Ubiquitin-associated protein-2 like | 1,087 | 9 | 8.34 |
| gi:20336294 | DHX30 | DExH box helicase 30 | 1,194 | 10 | 8.54 |
| gi:66347698 | C9ORF10 | Chromosome 9 open reading frame 10 | 1,118 | 7 | 6 |
| gi:2498883 | SF3B2 | Splicing factor 3b subunit 2 | 872 | 7 | 6.27 |
| gi:34222504 | FNBP3 | Formin-binding protein 3 | 957 | 2 | 1.9 |
| gi:18071115 | ATXN2L | Ataxin-2-related domain protein | 1,075 | 3 | 2.63 |
| gi:13124451 | POP1 | Ribonucleases P/MRP protein subunit | 1,024 | 2 | 1.86 |
| gi:12803113 | EFTUD2 | Elongation factor Tu GTP binding domain containing 2, U5 SnRNP component | 972 | 26 | 23 |
| gi:10047339 | MOV10 | Mov10 RISC complex RNA helicase | 1,032 | 9 | 8.16 |
| gi:40788339 | MATR3 | Matrin 3 | 853 | 6 | 5.57 |
| gi:4050087 | RBM25 | RNA binding motif protein 25 | 735 | 6 | 4.98 |
| gi:14141161 | HNRNPU | Heterogeneous nuclear ribonucleoprotein U | 806 | 4 | 3.49 |
| gi:11526793 | DHX36 | DEAH box helicase 36 | 1,008 | 5 | 4.57 |
| gi:14250756 | DDX24 | DEAD box helicase 24 | 859 | 4 | 3.56 |
| gi:11067747 | CDC5L | Cell division cycle 5 like | 802 | 12 | 10.5 |
| gi:128841 | NCL | Nucleolin | 707 | 7 | 6.08 |
| gi:10566459 | XAB2 | XPA binding protein 2 | 855 | 9 | 7.9 |
| gi:1699027 | TRIM28 | Tripartite motif containing 28 | 835 | 8 | 7.01 |
| gi:5032087 | SF3A1 | Splicing factor 3a subunit 1 | 793 | 7 | 5.96 |
| gi:29881667 | SFPQ | Splicing factor proline/glutamine-rich | 707 | 4 | 3.59 |
| gi:27477136 | ZC3HAV1 | Zinc finger CCCH-type antiviral protein 1 isoform 1 | 902 | 5 | 4.61 |
| gi:5762315 | NFAR-2 | Nuclear factor associated with dsRNA 2 | 894 | 6 | 5.44 |
| gi:168776622 | IFI-16 | Interferon, gamma-inducible protein 16 | 736 | 2 | 1.87 |
| gi:10863889 | SART1 | Squamous cell carcinoma antigen recognized by T cells 1 | 800 | 2 | 1.81 |
| gi:21619831 | TFIP11 | Tuftelin-interacting protein 11 | 837 | 2 | 1.81 |
| gi:2696613 | DDX46 | ATP-dependent RNA helicase 46 | 813 | 20 | 18.4 |
| gi:1857944 | SRPK2 | Serine/arginine-rich protein-specific kinase 2 | 686 | 4 | 3.43 |
| gi:2498733 | GP137 | GPI-anchored protein p137 | 709 | 4 | 3.67 |
| gi:14252988 | SRPK1A | Serine/arginine-rich protein-specific kinase 1a | 826 | 7 | 76.45 |
| gi:32880087 | DDX17 | DEAD box helicase 17 | 729 | 8 | 7.25 |
| gi:12653845 | AKAP8L | A kinase (PRKA) anchor protein 8 like | 646 | 2 | 1.86 |
| gi:10863945 | XRCC5 | X-Ray repair cross complementing 5, ATP-dependent DNA helicase II | 732 | 3 | 2.49 |
| gi:37925422 | NUFIP2 | Nuclear fragile X mental retardation-interacting protein 2, proliferation-inducing gene 1 | 695 | 4 | 3.48 |
| gi:1082856 | ILF3 | Interleukin enhancer binding factor 3 isoform a, transcription factor NF-AT 90K chain | 894 | 2 | 1.74 |
| gi:47125447 | ZNF326 | Zinc finger protein 326 | 508 | 14 | 12 |
| gi:73974124 | PABP1 | Polyadenylate binding protein 1 | 690 | 19 | 17.1 |
| gi:55632315 | HSP70 (HSPA5) | 78-kDa glucose-regulated protein | 654 | 11 | 10.3 |
| gi:2832596 | DDX17 | DEAD box helicase 17 | 729 | 13 | 11.5 |
| gi:14141152 | HNRNPM | Heterogeneous nuclear ribonucleoprotein M isoform a | 730 | 15 | 14 |
| gi:5454064 | RBM14 | RNA binding motif protein 14 | 669 | 5 | 4.48 |
| gi:73976763 | PABP4 | Polyadenylate-binding protein 4 | 644 | 13 | 11.6 |
| gi:31542501 | DEF6 | Differentially expressed in FDCP 6 | 631 | 4 | 3.63 |
| gi:30795212 | IGF-II 3 | Insulin-like growth factor 2 mRNA binding protein 3 | 579 | 18 | 16.1 |
| gi:56237027 | IGF-II 1 | Insulin-like growth factor 2 mRNA binding protein 1 | 577 | 8 | 7.07 |
| gi:30584123 | DDX5 | DEAD box helicase 5 | 615 | 10 | 8.51 |
| gi:228008400 | HNRNPQ | Heterogeneous nuclear ribonucleoprotein Q isoform 6 | 562 | 13 | 11.6 |
| gi:34783647 | SNW1 | SNW domain-containing protein 1 | 531 | 6 | 5.33 |
| gi:12751481 | SPATS2 | Spermatogenesis-associated, serine-rich 2 | 545 | 4 | 3.78 |
| gi:15022507 | COAA | Coactivator activator | 669 | 2 | 1.87 |
| gi:14165437 | HNRNPK | Heterogeneous nuclear ribonucleoprotein K | 464 | 20 | 17.9 |
| gi:2808511 | NONO | Non-POU domain-containing octamer binding protein | 471 | 7 | 6.25 |
| gi:15809586 | HNRNPQ | Heterogeneous nuclear ribonucleoprotein Q isoform 1 | 623 | 2 | 1.84 |
| gi:10835067 | SSB | Sjogren syndrome antigen B, autoantigen LA | 408 | 12 | 10.9 |
| gi:12655035 | RPL4 | Ribosomal protein L4 | 427 | 10 | 8.78 |
| gi:15620927 | PNMA5 | Paraneoplastic Ma antigen family member 5 | 452 | 9 | 7.98 |
| gi:18088719 | TUBB | Tubulin beta polypeptide | 444 | 8 | 7.03 |
| gi:181486 | DBPB | DNA binding protein B | 364 | 8 | 7.53 |
| gi:13177790 | DDX48 | DEAD box polypeptide 48 | 411 | 15 | 13.3 |
| gi:16876910 | HNRNPF | Heterogeneous nuclear ribonucleoprotein F | 415 | 8 | 7.23 |
| gi:14250148 | RPL3 | Ribosomal protein L3 | 403 | 9 | 7.84 |
| gi:12655035 | RPL4 | Ribosomal protein L4 | 427 | 5 | 4.27 |
| gi:12654229 | EIF2S2 | Eukaryotic translation initiation factor 2 beta | 333 | 3 | 2.74 |
| gi:1167838 | YBX3 | Y box binding protein 3, DNA binding protein | 372 | 2 | 1.78 |
| gi:2072950 | p40 | LINE retrotransposable element 1 | 338 | 6 | 5.46 |
| gi:532313 | ILF2(NF45) | Interleukin enhancer binding factor 2 | 406 | 6 | 5.45 |
| gi:14249959 | HNRNPC | Heterogeneous nuclear ribonucleoprotein C (C1/C2) | 293 | 10 | 9.04 |
| gi:444021 | PCBP1 | Poly(rC) binding protein 1, Sub2.3 | 299 | 5 | 4.53 |
| gi:18490263 | RPL6 | Ribosomal protein L6 | 288 | 5 | 4.27 |
| gi:14043072 | HNRNPA2B1 | Heterogeneous nuclear ribonucleoprotein A isoform B1 | 353 | 2 | 1.8 |
| gi:18089152 | DRG1 | Developmentally regulated GTP binding protein 1 | 367 | 4 | 3.32 |
| gi:12654583 | RPLP0 | Ribosomal protein P0 | 317 | 5 | 4.44 |
| gi:1314308 | RARA | Nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form | 563 | 3 | 2.82 |
| gi:133252 | HNRNPA1 | Heterogeneous nuclear ribonucleoprotein A1 | 195 | 3 | 2.74 |
| gi:4377849 | TRA2B | Transformer-2-beta isoform 3 | 188 | 3 | 2.54 |
| gi:48376549 | RPS4X | Ribosomal protein S4, X linked | 243 | 8 | 6.79 |
| gi:1096067 | TAP | Tat-associated protein | 279 | 4 | 3.81 |
| gi:15928608 | SLC25A6 | Solute carrier family 25, member A6 | 298 | 3 | 2.44 |
| gi:14198272 | PGAM5A | Phosphoglycerate mutase family member 5 | 255 | 2 | 1.74 |
| gi:14714596 | H1FX | H1 histone family member X | 213 | 2 | 1.85 |
| gi:21410831 | SAP | Sin3A-associated protein | 153 | 5 | 4.67 |
| gi:32959908 | SNRNPD1 | Small nuclear ribonucleoprotein D1 polypeptide | 119 | 4 | 3.4 |
| gi:1070593 | HIST1H1C | Histone cluster 1 H1 family member C, histone (10.5)1.1 | 213 | 3 | 2.65 |
| gi:122009 | HIST1H2AG | Histone H2A.1 | 129 | 2 | 1.68 |
a
Accession numbers may be found in the NCBI Protein database (https://www.ncbi.nlm.nih.gov/protein/).
b
Number of polypeptides detected for the protein by MS.