FIG 7.

Translational changes of CRISPR-identified host factors during DENV infection. (A) Histogram showing changes in total translation for CRISPR-identified essential genes for DENV2 as determined in Marceau et al. (27). Genes that were essential for DENV replication and with a RIGER score of >1 were operationally scored as essential, while all other genes were scored as nonessential. (B) List of log₂ change in translation for CRISPR-identified essential genes for DENV2 as determined in Marceau et al. (27), with a RIGER score of >1, after 40 h of infection. These values were calculated as described in Materials and Methods. The ER localization status of each gene product is also indicated.