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. 2018 May 4;9(1):230–245. doi: 10.1080/19491034.2018.1460185

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Transcriptional regulation of LA, P, and LC by retinoid compounds. (A) Top: cartoon illustrating HGPS iPS-MSCs on soft/stiff gels treated with retinoid compounds, all-trans retinoic acid (RA) and antagonist (AGN). Bottom: immunofluorescence quantitation of total A-type lamins after treatment with retinoids CD1530 (agonist) and CD2665 (antagonist) on soft or stiff gel cultures. (B) Western blot of early passage (P2) HGPS iPS-MSCs treated with 1 μM RA or AGN on rigid plastic. (C) Sensitivity to transcriptional regulation by retinoids decreases with passage.