Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Potential roles of DICER and MMSET mediated H4K20me2 in nucleotide excision repair. UV damage results in recruitment of DICER to the DNA lesion. DICER mediates chromatin decondensation via PARP1 activation, and setting of the H4K20me2 mark via MMSET recruitment. This may further lead to cell cycle regulation via 53BP1 binding, limiting of DNA decondensation via methylation of H4K20, and potentially reciprocal regulation of XPA and PARP1 binding via changes in parylation.
