Table 2. Treatment of MosMes-Pik3ca^H1047R mice with rapamycin.

Mouse #	1	2	3	4	5	6
Sex	m	m	m	f	m	f
Phenotype	Subcutaneous VM at right flank, phlebectasia of portal vein and inferior vena cava	Subcutaneous VM at left flank, phlebectasia of portal vein and inferior vena cava	Subcutaneous VM at the base of the tail, below left hind limb	Phlebectasia of portal vein and inferior vena cava. No VM detected by CT-A.	WT control	WT control
Age at starting treatment*	8-week-old	8-week-old	10-week-old	5-week-old	10-week-old	5-week-old
Duration of treatment	4 weeks	2 weeks	6 weeks	4 weeks	6 weeks	4 weeks
Outcome	VM volume reduction: 32.4% at 2 weeks; 65% at 4 weeks. Normalization of phlebectasias in portal vein and inferior vena cava. Cessation of bleeding of lesion after 1 week of treatment. VM no longer detected upon necropsy 4 weeks after treatment.	No volume reduction, mouse became ill after 2 weeks and had to be sacrificed in line with UK Home Office regulations.	VM volume reduction: 18.7% at 2 weeks, 28.4% at 4 weeks, 37% at 6 weeks. Cessation of rectal bleeding immediately after treatment	Normalization of portal vein and inferior vena cava phlebectasia	Overall healthy	Overall healthy

^*Mice were treated with rapamycin, 4 mg/kg every other day