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SCLC患者外周血中CD8⁺PD-1⁺及CD4⁺CD25⁺CTLA-4⁺与临床病理因素的关系

The relationship between CD8⁺PD-1⁺ and CD4⁺CD25⁺CTLA-4⁺ level and clinicopathologic parameters in the patients with SCLC

Pathologic parameter	n	PD-1 (%)	P	CTLA-4 (%)	P
SCLC: small cell lung cancer; ECOG: Eastern Cooperative Oncology Group; PS: performance status; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease.
Gender			0. 453		0.391
Male	174	11.67±5.02		7.25±4.68
Female	116	11.18±6.01		6.76±4.98
Age (yr)			0.809		0.449
≥60	141	11.39±5.71		7.27±5.12
< 60	149	11.55±5.71		6.84±4.48
Smoking status			0.819		0.466
No	110	11.42±5.33		6.88±4.459
Yes	180	11.57±5.62		7.33±5.32
ECOG PS			0.663		0.276
0-1	270	11.51±5.39		6.97±4.71
2-3	20	10.96±6.02		8.78±5.16
Response			0.409		0.287
CR+PR+SD	248	11.38±5.56		7.20±4.78
PD	42	12.14±5.10		6.50±1.11
Pathological stage			0.267		0.552
Limited stage	176	11.18±5.09		7.19±4.939
Extensive stage	114	11.91±5.10		6.85±4.62
Metastases			0.882		0.942
Yes	111	11.53±5.81		7.03±4.70
No	179	11.44±5.20		7.07±4.87