1.

HARS转染角质细胞移植至免疫同源FVB/N小鼠背部成瘤。A：基因组EGFR^flx/flx肿瘤生长较野生基因型组EGFR^wt/wt迟缓；B：药理组连续1周系统性喂食吉非替尼小鼠体积较对照组较小。^*P＜0.05。

Tumors originated from HRAS transformed FVB/N primary keratinocytes grafted on the back of immunocompetent syngeneic mice. A: EGFR^flx/flx keratinocytes that formed the malignant squamous tumors are smaller formed from than the EGFR^wt/wt; B: Pharmacological blockade of EGFR by systemic administration of gefitinib or 10% DMSO for 1 week, the former tumors are smaller. ^*P < 0.05.