Table 1.
Model of GABAA receptor subtypes and their contribution toward benzodiazepine’s psychopharmacological effects
| Reference GABAA Receptor |
25, 28, 35–39, 49–52 α1 |
28, 35–39, 49–52, 64 α2 |
29–41,50–53, 65 α3 |
26–39, 42–49 α5 |
|---|---|---|---|---|
| Sedation |
|
|
|
|
| Addiction |
|
|
|
|
| Anxiolysis |
|
|
|
|
| Myorelaxation |
|
|
|
|
| Anticonvulsive |
|
|
|
|
| Amnesia |
|
|
|
|
|
| ||||
| Key: contribution toward clinical effect |
 Negligible |
 Minor |
 Moderate |
 Significant |
Abbreviation: GABA, gamma aminobutyric acid.