Table S1.
Proportion of patients with an FEV1 response on Day 28 (ie, change from baseline in morning pre-dose FEV1≥100 mL; ITT population)
| GB
|
Placebo (n=115) | ||||
|---|---|---|---|---|---|
| 6.25 µg BID (n=116) | 12.5 µg BID (n=111) | 25 µg BID (n=119) | 50 µg BID (n=112) | ||
| Responder, n (%) | 47 (42.3) | 47 (43.1) | 62 (53.9) | 66 (60.6) | 19 (17.8) |
| Odds ratio (95% CI) vs placebo | 12.5 (4.1; 37.8) | 7.8 (2.8; 21.7) | 13.0 (4.5; 37.5) | 19.5 (6.5; 58.3) | |
| p-value vs placebo | <0.001 | <0.001 | <0.001 | <0.001 | |
Abbreviations: BID, twice daily; FEV1, forced inspiratory volume in 1 s; GB, glycopyrronium bromide; ITT, intention-to-treat.