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(A) Effect of HCA to the activation of t-PA; (B) The indirect inhibitory effects of HCA and ancrod on the acceleration of FXa to t-PA-catalyzed plasminogen activation. S2403 is a kind of chromogenic substrate. The values shown are the mean ± SEM (n=3).
Abbreviations: FXa, active factor X; HCA, hemocoagulase agkistrodon; Lys-Pg, Lys-plasminogen; NS, normal saline; PCPS, small unilamellar phospholipid vesicles; t-PA, tissue plasminogen activator.
