Table 5.
Association between rs17014601 and risk of COPD in different inheritance models
| Model | Genotypes | Cases n (%) | Controls n (%) | Non-adjusted model
|
Adjustment I model
|
Adjustment II model
|
|||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | P-valuea | OR (95% CI) | P-valueb | OR (95% CI) | P-valuec | ||||
| Additive | 1.32 (1.10–1.59) | 0.0032 | 1.33 (1.11–1.61) | 0.0025 | 1.36 (1.11–1.67) | 0.0028 | |||
| TT | 203 (42.4) | 321 (53.9) | 1 | 1 | 1 | ||||
| Heterozygote | CT | 232 (48.4) | 222 (37.3) | 1.65 (1.28–2.13) | 0.0001 | 1.66 (1.29–2.15) | 0.0001 | 1.76 (1.33–2.32) | 0.0001 |
| Homozygote | CC | 44 (9.2) | 53 (8.9) | 1.31 (0.85–2.03) | 0.2219 | 1.33 (0.86–2.07) | 0.1967 | 1.34 (0.83–2.17) | 0.2245 |
| Dominant | CT+CC | 276 (57.6) | 275 (46.1) | 1.59 (1.25–2.02) | 0.0002 | 1.60 (1.26–2.04) | 0.0001 | 1.67 (1.28–2.18) | 0.0001 |
| Recessive | TT+CT | 435 (90.8) | 543 (91.1) | 1 | 1 | 1 | |||
| CC | 44 (9.2) | 53 (8.9) | 1.04 (0.68–1.58) | 0.8676 | 1.05 (0.69–1.60) | 0.8230 | 1.03 (0.65–1.62) | 0.9014 | |
Notes: The Benjamini and Hochberg FDR method was used to adjust the multiple hypothesis tests, standard α=0.05.
a
Unadjusted model.
b
Adjustment I model was adjusted for age and sex.
c
Adjustment II model was adjusted for age, sex, BMI, smoking status, pack-years smoked, coal consumption, family history of lung disease, and childhood history of respiratory disease.
Abbreviations: COPD, chronic obstructive pulmonary disease; OR, odds ratio; CI, confidence interval; FDR, false discovery rate; BMI, body mass index.