Table 3.

Association between PI3KCA rs6443624 and clinicopathological features of 328 breast cancer patients

Parameters	PI3KCA rs6443624
	CC	AC	AA	AC+AA
Age (years)
≤50/>50	14/44	42/108	32/88	74/196
OR (95% CI)	1.00	0.82 (0.41–1.65)	0.88 (0.42–1.81)	0.84 (0.44–1.63)
R2 value		1.52E-3	7.29E-4	7.84E-4
p-value		0.573	0.718	0.610
Tumor size (cm)
≤2/>2	10/48	40/110	22/98	62/208
OR (95% CI)	1.00	0.57 (0.27–1.24)	0.93 (0.41–2.11)	0.79 (0.33–1.46)
R2 value		9.80E-3	1.69E-4	2.81E-3
p-value		0.154	0.859	0.340
Stage
I+II/III+IV	49/9	106/44	87/33	193/77
OR (95% CI)	1.00	2.26 (1.02–4.99)	2.07 (0.91–4.67)	2.17 (1.05–4.49)
R2 value		2.02E-2	1.74E-2	1.37E-2
p-value		0.040	0.078	0.034*
Grade
I+II/III	31/27	63/87	44/76	107/163
OR (95% CI)	1.00	1.59 (0.86–2.92)	1.98 (1.05–3.75)	1.75 (0.99–3.10)
R2 value		1.06E-2	2.53E-2	1.14E-2
p-value		0.137	0.034	0.053
Lymph node invasion
No/yes	32/26	76/74	51/69	126/143
OR (95% CI)	1.00	1.20 (0.65–2.20)	1.67 (0.89–3.13)	1.55 (0.88–2.75)
R2 value		1.60E-3	1.42E-2	7.06E-3
p-value		0.560	0.112	0.129
ER status
Negative/positive	24/34	61/89	61/59	122/148
OR (95% CI)	1.00	1.03 (0.56–1.91)	0.68 (0.36–1.29)	0.86 (0.48–1.52)
R2 value		4.90E-5	7.92E-3	8.41E-4
p-value		0.925	0.237	0.597
PR status
Negative/positive	22/36	60/90	57/63	117/153
OR (95% CI)	1.00	0.92 (0.49–1.71)	0.68 (0.36–1.28)	0.80 (0.45–1.43)
R2 value		3.61E-4	8.10E-3	1.76E-3
p-value		0.784	0.228	0.450
HER2 status
Negative/positive	42/16	119/31	81/39	200/70
OR (95% CI)	1.00	0.68 (0.34–1.38)	1.26 (0.63–2.52)	0.92 (0.49–1.74)
R2 value		5.48E-3	2.50E-3	1.96E-4
p-value		0.285	0.506	0.794

Note:

^*p<0.05, as compared to CC genotype.