Table 2.

Modulation of lipid profile and liver enzymes by isotretinoin therapy (n = 200)

Parameter	Measure	Before isotretinoin therapy	After isotretinoin therapy
Lipid profile (mmol/L)	HDL	1.41 ± 0.24	1.32 ± 0.32*
	LDL	2.33 ± 0.71	2.78 ± 0.76*
	TC	4.141 ± 0.88	4.61 ± 0.97*
	TG	0.99 ± 0.57	1.32 ± 0.77*
Liver function enzymes (U/L)	AST	18.61 ± 4.97	21.71 ± 9.84*
	ALT	15.71 ± 9.01	17.73 ± 12.30*

Notes: Data expressed as mean ± standard deviation.

^*Significant difference (P < 0.01).

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride.