Table 3.
The impact of rs7799039 genotypes on biochemical parameters that are modulated by isotretinoin (n = 200)
| Parameter | Genotypes (mean ± SD)
|
||
|---|---|---|---|
| CC | AC | AA | |
| HDL (mmol/L) | |||
| Baseline | 1.30 ± 0.29* | 1.4 ± 0.27 | 1.37 ± 0.31 |
| After treatment | 1.26 ± 0.31* | 1.36 ± 0.28 | 1.33 ± 0.29 |
| % change | −9.54 ± 1.58* | −3.03 ± 1.77$ | −9.54 ± 1.20 |
| LDL (mmol/L) | |||
| Baseline | 2.37 ± 0.61 | 2.30 ± 0.82 | 2.30 ± 0.62 |
| After treatment | 2.81 ± 0.70 | 2.80 ± 0.88 | 2.69 ± 0.55 |
| % change | 1.95 ± 2.08# | 2.73 ± 2.11 | 2.02 ± 1.96 |
| TC (mmol/L) | |||
| Baseline | 4.02 ± 0.85 | 4.24 ± 0.98 | 4.10 ± 0.70 |
| After treatment | 4.55 ± 0.97 | 4.67 ± 1.09 | 4.59 ± 0.63 |
| % change | 1.03 ± 1.29$ | 1.44 ± 1.42 | 9.92 ± 1.25 |
| TG (mmol/L) | |||
| Baseline | 0.97 ± 0.55 | 1.04 ± 0.65 | 0.91 ± 0.40 |
| After treatment | 1.22 ± 0.71 | 1.45 ± 0.89 | 1.21 ± 0.50 |
| % change | 45.5 ± 116.9 | 40.6 ± 56.7 | 29.4 ± 44.4 |
| AST (U/L) | |||
| Baseline | 18.40 ± 4.12 | 19.46 ± 6.04£ | 17.00 ± 2.73 |
| After treatment | 20.61 ± 6.05 | 23.40 ± 10.0£ | 19.72 ± 4.75 |
| % change | 1.956 ± 3.70 | 1.88 ± 2.52 | 1.28 ± 3.72 |
| ALT (U/L) | |||
| Baseline | 15.56 ± 10.34 | 17.12 ± 9.35£ | 12.68 ± 3.26 |
| After treatment | 16.9 ± 9.15 | 19.44 ± 9.85£ | 15.14 ± 5.55 |
| % change | 17.41 ± 43.67 | 23.81 ± 50.69 | 14.07 ± 69.84 |
Notes:
*
CC genotype is significantly different from AC genotype.
$
A significant difference of CC genotype with AC genotype.
#
A significant difference of CC with other genotypes.
£
A significant difference of AC genotype with other genotypes.
Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride.