Table 4.
ARs of mecillinam as monotherapy or combined with AMP
| Reference | Therapy | Exanthema | GI | Others | Total AR | Total SAR |
|---|---|---|---|---|---|---|
| Frimodt-Møller and Ravn32 | MEC or MEC/AMP | 0 | 0 | 0 | 0/5 | 0/5 |
| Ekwall et al30,a | MEC/AMP, P-MEC/P-AMP | 4 | 0 | 0 | 5/73 | 0/73 |
| Ekwall et al30 | MEC/P-MEC | 1 | 0 | 0 | ||
| Ode et al39 | MEC/P-MEC | 1 | 2 | 0 | 3/20 | 0/20 |
| Trollfors et al38 | MEC/P-MEC | 0 | 0 | 0 | 0/25 | 0/25 |
| Helin33 (pediatric) | P-MEC | 0 | 0 | 0 | 0/19 | 0/19 |
| Eriksson et al31 | MEC/AMP | 7 | 4 | 5 | 16/43 | 0/43 |
| Jernelius et al34 | P-MEC/P-AMP | 1 | 2 | 2 | 5/38 | 0/38 |
| Jernelius et al34 (21 days) | P-MEC/P-AMP | 0 | 11 | 1 | 12/39 | 0/39 |
| Cronberg et al29 | MEC/AMP, P-MEC/P-AMP | 12 | 15 | 5 | 32/144 | 0/144 |
| Total | Cumulative | 26 | 34 | 13 | 73/406b (18%) | 0/406 (0%) |
| Total | MEC | 2 | 2 | 0 | 4 | 0 |
| Total | MEC/AMP | 24 | 32 | 13 | 69 | 0 |
Notes: We did not include the studies that did not report, specify, and/or categorize the side effects.
a
Half had double dose.
b
Some patients had more than one AR.
Abbreviations: AMP, ampicillin; AR, adverse reaction; GI, gastrointestinal; MEC, mecillinam; P-AMP, pivampicillin; P-MEC, pivmecillinam; SAR, serious adverse reaction.