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. 2018 May 24;12:1453–1466. doi: 10.2147/DDDT.S154334

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© 2018 Li and Zhang. This work is published and licensed by Dove Medical Press Limited

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Changes in (A) body weight, (B) blood glucose, and (C) insulin concentration of the type 2 diabetic group and the normal group during the feeding period. The ROS in the supernatant was determined by measuring (D) H₂O₂ and (E) TBARS level. (F) The intracellular ROS was evaluated by DCF fluorescence. The mitochondrial status was evaluated by Western blot of (G) MnSOD and (H) NOX4 expression.

Notes: ***P<0.001 vs the normal group (A–C); vs the NS group (D–H). ^##P<0.01 vs the DS group; ^###P<0.001 vs the DS group.

Abbreviations: ROS, reactive oxygen species; TBARS, thiobarbituric acid reactive substances; DCF, 2′,7′-dichlorofluorescein diacetate; NS, normal serum; DS, diabetic serum; Cur, curcumin.