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. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Radiat Res. 2018 Mar 27;189(6):560–578. doi: 10.1667/RR14878.1

FIG. 4 — Histopathologic appearance of oral cavity tissue after single-fraction or fractionated head and neck irradiation of Fancg^−/− mice and amelioration of radiation damage by JP4-039/F15 treatment. Groups of mice (Fancg^−/−, Fancg^+/− and Fancg^+/+; n = 5 per group) were head and neck irradiated with a single 30 Gy fraction (panels A and C) or four successive days of 10 Gy (panels B and D) and all evaluated at 5 days after the final radiation fraction. Panels A and B: H&E staining (×100) for single-fraction and fractionated irradiation groups, respectively. Black ← arrows indicate normal epithelium; red arrows indicate damaged/ ulcerated epithelium. Panels C and D: Damage quantitation after single-fraction and fractionated irradiation, respectively. In panel C, for Fancg^+/+, Fancg^+/− and Fancg^−/− values, respectively, when JP4-039 is compared to 30 Gy, *P = 0.1859, *P = 0.0230 and *P = 0.0312; when JP4-039 is compared to 30 Gy + F15, ^#P < 0.2571, ^#P < 0.5987 and ^#P < 0.008; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P < 0.7889, ^P < 0.3051 and ^P < 0.0132. For Fancg^+/+, Fancg^+/− and Fancg^−/− values in panel D, P < 0.0001 when JP4-039 is compared to *30 Gy, ^#30 Gy + F15 or ^30 Gy + 4-amino-Tempo/F15.

FIG. 4 — Histopathologic appearance of oral cavity tissue after single-fraction or fractionated head and neck irradiation of Fancg^−/− mice and amelioration of radiation damage by JP4-039/F15 treatment. Groups of mice (Fancg^−/−, Fancg^+/− and Fancg^+/+; n = 5 per group) were head and neck irradiated with a single 30 Gy fraction (panels A and C) or four successive days of 10 Gy (panels B and D) and all evaluated at 5 days after the final radiation fraction. Panels A and B: H&E staining (×100) for single-fraction and fractionated irradiation groups, respectively. Black ← arrows indicate normal epithelium; red arrows indicate damaged/ ulcerated epithelium. Panels C and D: Damage quantitation after single-fraction and fractionated irradiation, respectively. In panel C, for Fancg^+/+, Fancg^+/− and Fancg^−/− values, respectively, when JP4-039 is compared to 30 Gy, *P = 0.1859, *P = 0.0230 and *P = 0.0312; when JP4-039 is compared to 30 Gy + F15, ^#P < 0.2571, ^#P < 0.5987 and ^#P < 0.008; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P < 0.7889, ^P < 0.3051 and ^P < 0.0132. For Fancg^+/+, Fancg^+/− and Fancg^−/− values in panel D, P < 0.0001 when JP4-039 is compared to *30 Gy, ^#30 Gy + F15 or ^30 Gy + 4-amino-Tempo/F15.