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. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Radiat Res. 2018 Mar 27;189(6):560–578. doi: 10.1667/RR14878.1

FIG. 5 — Histopathologic appearance of oral cavity tissue after single-fraction or fractionated head and neck irradiation of Fanca^−/− mice and amelioration by JP4-039/F15 of radiation damage. Groups of mice (Fanca^−/−, Fanca^+/− and Fanca^+/+; n =5 per group) were head and neck irradiated with a single 30 Gy fraction (panels A and C) or four successive days of 10 Gy (panels B and D) and all evaluated at 5 days after the final fraction. Panels A and B: H&E staining for single-fraction and fractionated irradiation groups, respectively. Black arrows indicate normal epithelium; red ← arrows indicate damaged/ulcerated epithelium. Panels C and D: Damage quantitation after single-fraction and fractionated irradiation, respectively. In panel C, for Fanca^+/+, Fanca^+/− and Fanca^−/− values, respectively, when JP4-039 is compared to 30 Gy, *P < 0.0054, *P < 0.0075 and *P < 0.05042; when JP4-039 is compared to 30 Gy + F15, ^#P < 0.0005, ^#P < 0.2188 and ^#P < 0.0203; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P < 0.0002, ^P < 0.1435 and ^P < 0.0045. For Fanca^+/+, Fanca^+/− and Fanca^−/− values in panel D, when JP4-039 is compared to 30 Gy, *P < 0.0001, *P < 0.0001 and *P =0.0002; when JP4-039 is compared to 30 Gy + F15, ^#P = 0.0006, ^#P = 0.0082 and ^#P < 0.0001; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P =0.0065, ^P =0.1015 and ^P < 0.0001.

FIG. 5 — Histopathologic appearance of oral cavity tissue after single-fraction or fractionated head and neck irradiation of Fanca^−/− mice and amelioration by JP4-039/F15 of radiation damage. Groups of mice (Fanca^−/−, Fanca^+/− and Fanca^+/+; n =5 per group) were head and neck irradiated with a single 30 Gy fraction (panels A and C) or four successive days of 10 Gy (panels B and D) and all evaluated at 5 days after the final fraction. Panels A and B: H&E staining for single-fraction and fractionated irradiation groups, respectively. Black arrows indicate normal epithelium; red ← arrows indicate damaged/ulcerated epithelium. Panels C and D: Damage quantitation after single-fraction and fractionated irradiation, respectively. In panel C, for Fanca^+/+, Fanca^+/− and Fanca^−/− values, respectively, when JP4-039 is compared to 30 Gy, *P < 0.0054, *P < 0.0075 and *P < 0.05042; when JP4-039 is compared to 30 Gy + F15, ^#P < 0.0005, ^#P < 0.2188 and ^#P < 0.0203; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P < 0.0002, ^P < 0.1435 and ^P < 0.0045. For Fanca^+/+, Fanca^+/− and Fanca^−/− values in panel D, when JP4-039 is compared to 30 Gy, *P < 0.0001, *P < 0.0001 and *P =0.0002; when JP4-039 is compared to 30 Gy + F15, ^#P = 0.0006, ^#P = 0.0082 and ^#P < 0.0001; and when JP4-039 is compared to 30 Gy + 4-amino-Tempo/F15, ^P =0.0065, ^P =0.1015 and ^P < 0.0001.