Table 1.
Selection of key BGC gene correlations between keyicin and nogalamycin clusters
| kyc gene | Nogalamycin BGC gene | Accession # for kyc gene | Accession # for nogalamycin gene | Putative function for established gene product | % identity |
|---|---|---|---|---|---|
| kyc9 | snoaM51 | OHX01513.1 | AAF01818.1 | polyketide cyclase | 78% |
| kyc17 | snoK44 | OHX01520.1 | AAF01812.1 | non-heme iron α-ketoglutarate (α-KG)–dependent carbocyclase | 62% |
| kyc25 | snogE51-53 | OHX01526.1 | AAF01809.1 | GT for nogalose | 62% |
| kyc34 | snoaL48 | OHX01535.1 | AAF01813.1 | nogalonic acid methyl ester (NAME) cyclase | 77.8% |
| kyc36 | snoaW49, 54 | OHX01536.1 | AAF01810.1 | putative hydroxylase (in tandem with SnoaL2) | 60.7% |
| kyc44 | snogA55 | OHX01543.1 | AAF01819.1 | amino methyltransferase | 67.2% |
| kyc51 | snoaL249 | OHX01549.1 | AAF01808.1 | C-1 hydroxylase component (in tandem with SnogW) | 63.2% |
| kyc52 | snogD50, 52, 53 | OHX01550.1 | AAF01811.1 | GT (specifically, nogalamine-transferase) | 65% |
| kyc54 | snoN44 | OHX01552.1 | AAF01805.1 | SnoK homolog with epimerase role | 71% |