Fig 3. Effects of variation in D1R-sensitivity on the critical DA releasability, on the critical as well as saturations levels of cortical DA content, and on the modulation-associated windows of DA content and D1R stimulation.
Increase in D1Rsens causes significant decrease in the critical RDA (A) and [DA] (B) marking an early beginning of the bifurcation regime. The variations in critical RDA and [DA] (C) exhibit a strong positive correlation. Moreover, the saturation level of [DA] (D) significantly decreases with increase in D1Rsens, causing the modulation-associated window of DA (E) to shift to lower values as well as shrinks in its span. However, the modulation-associated window of D1R stimulation (F) does not vary with change in D1Rsens.