Fig 3. Evolution of the adjusted geometric mean plasma values of homocysteine from baseline through the 4.7 years of follow-up (with adjustment for sex, baseline plasma creatinine, type of prevalent CVD, vitamin B₆, vitamin B₁₂ and folate) among the three MTHFR genotypes and by supplementation group.

Approximately half of patients not supplemented with B-vitamins and half of patients supplemented with B-vitamins were supplemented by n-3 fatty acids. The groups were merged because n-3 fatty acids supplementation did not interact with B-vitamin supplementation. The SU.FOL.OM3 trial (2003–2009).