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. 2018 Mar 14;10(4):572–582. doi: 10.1080/19420862.2018.1442998

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© 2018 Amgen Inc, Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 8. — CID MS³ spectrum of the disulfide-dissociated peptide TH23 within the C_H2 domain. TH23 was identified by Proteome Discoverer as a reduced peptide resulting from disulfide cleavage with multiple fragment ions serving as anchors to aid in confident identification of peptide segment. The dipeptide TH28 was confirmed to be the complementary peptide based on the mass difference between the disulfide-linked peptide and the identified disulfide-dissociated TH23, leading to the identification of disulfide linkage between C²⁷⁰ (H) and C³³⁰ (H).