Table 1.
Demographics of female and male subjects by major depression status and antidepressant use in the female partner.
| FEMALE SUBJECTS | MALE SUBJECTS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PHQ-9 < 10 No antidepressant (N=1359) |
PHQ-9 < 10 On antidepressant (N=73) |
PHQ-9 ≥ 10 No antidepressant (N=72) |
PHQ-9 ≥ 10 On antidepressant (N=16) |
P value | PHQ-9 < 10 (N=1455) |
PHQ-9 ≥ 10 (N=34) |
P value | |||
| Age, average (SD) | 30.77 (4.48) | 31.03 (4.56) | 28.42 (4.59) | 30 (3.39) | 0.0002 | 33.05 (5.76) | 32.71 (5.45) | 0.83 | ||
| BMI, average (SD) | 30.14 (8.75) | 32.22 (8.32) | 36.7 (9.32) | 37.58 (7.59) | 0.0001 | 29.34 (6.48) | 31.00 (7.16) | 0.19 | ||
| Months trying to conceive, average (SD) | 36.14 (29.94) | 45.07 (39.89) | 51.26 (43.17) | 26.19 (17.86) | 0.006 | 37.30 (30.42) | 37.18 (31.96) | 0.73 | ||
| AMH (female), average (SD) | 5.07 (5.63) | 4.70 (3.6) | 6.03 (4.58) | 6.30 (5.85) | 0.01 | 5.05 (5.51) | 3.83 (3.85) | 0.2 | ||
| PHQ-9 score, average (SD) | 2.10 (2.38) | 3.33 (2.65) | 12.78 (2.62) | 13.13 (3.90) | 0.0001 | 1.21 (1.83) | 13.41 (4.24) | 0.0001 | ||
| Race, N (%) | 0.4 | 0.6 | ||||||||
| white | 1096 (80.65%) | 66 (90.41%) | 56 (77.78%) | 14 (87.5%) | 1156 (79.45%) | 28 (82.35%) | ||||
| black | 138 (10.15%) | 2 (2.74%) | 9 (12.5%) | 1 (6.25%) | 190 (13.06%) | 5 (14.71%) | ||||
| other | 125 (9.2%) | 5 (6.85%) | 7 (9.72%) | 1 (6.25%) | 109 (7.49%) | 1 (2.94%) | ||||
| History smoking, N(%) | 495 (36.42%) | 39 (53.42%) | 42 (58.33%) | 7 (43.75%) | < 0.0001 | 694 (47.8%) | 19 (55.88%) | 0.35 | ||
| Current smoking, N(%) | 139 (10.23%) | 12 (16.44%) | 17 (23.61%) | 1 (6.25%) | 0.002 | 260 (17.91%) | 9 (26.47%) | 0.2 | ||
| Eduction, N(%) | 0.22 | 0.83 | ||||||||
| 8th grade or less | 6 (0.44%) | - | - | - | 17 (1.17%) | - | ||||
| some high school | 37 (2.72%) | 1 (1.37%) | 2 (2.78%) | 1 (6.25%) | 82 (5.65%) | 1 (2.94%) | ||||
| high school graduate | 146 (10.74%) | 7 (9.59%) | 14 (19.44%) | 2 (12.5%) | 280 (19.3%) | 7 (20.59%) | ||||
| some college | 371 (27.3%) | 24 (32.88%) | 27 (37.5%) | 5 (31.25%) | 422 (29.08%) | 13 (38.24%) | ||||
| college graduate | 510 (37.53%) | 31 (42.47%) | 23 (31.94%) | 6 (37.5%) | 444 (30.6%) | 9 (26.47%) | ||||
| graduate degree | 289 (21.27%) | 10 (13.7%) | 6 (8.33%) | 2 (12.5%) | 206 (14.2%) | 4 (11.76%) | ||||
| Income (household), N(%) | < 0.0001 | 0.43 | ||||||||
| < $25,000 | 83 (6.11%) | 5 (6.85%) | 14 (19.44%) | 1 (6.25%) | 102 (7.01) | 5 (14.71) | ||||
| $25,000 to $49,999 | 272 (20.01%) | 14 (19.18%) | 20 (27.78%) | 1 (6.25%) | 279 (19.18) | 9 (26.47) | ||||
| $50,000 to $74,999 | 319 (23.47%) | 27 (36.99%) | 16 (22.22%) | 6 (37.5%) | 356 (24.47) | 6 (17.65) | ||||
| $75,000 to $100,000 | 263 (19.35%) | 14 (19.18%) | 7 (9.72%) | 4 (25%) | 282 (19.38) | 5 (14.71) | ||||
| > $100,000 | 207 (15.23%) | 8 (10.96%) | 2 (2.78%) | 1 (6.25%) | 213 (14.64) | 4 (11.76) | ||||
| Previous live birth, N(%) | 278 (20.46%) | 17 (23.29%) | 12 (16.67%) | 4 (25%) | 0.75 | 281 (19.31) | 11 (32.35) | 0.06 | ||
| Study, N(%) | < 0.0001 | 0.93 | ||||||||
| AMIGOS | 771 (56.73%) | 35 (47.95%) | 11 (15.28%) | 2 (12.5%) | 824 (56.63%) | 19 (55.88%) | ||||
| PPCOS II | 588 (43.27%) | 38 (52.05%) | 61 (84.72%) | 14 (87.5%) | 631 (43.37%) | 15 (44.12%) | ||||
| Partner PHQ-9 ≥ 10, N (%) | 26 (2.05%) | 1 (1.56%) | 4 (7.02%) | 0 | 0.09 | 70 (4.89) | 4 (12.12) | 0.06 | ||
| Sperm concentration (million per mL), average (SD) | 72.63 (65.96) | 69.76 (61.01) | 86.85 (79.60) | 73.86 (29.01) | 0.36 | 73.59 (66.37) | 73.65 (74.77 | 0.94 | ||
| Partner age, average years (SD) | 32.96 (5.61) | 33.92 (6.11) | 32.17 (6.69) | 31.93 (3.35) | 0.26 | 30.75 (4.52) | 30.44 (4.94) | 0.75 | ||
| Female antidepressant use, N(%) | - | - | - | - | 75 (5.38%) | 1 (3.13%) | 0.32 | |||