Figure 1. Integrin α_Mβ₂ deficiency enhances atherosclerosis in female ApoE^−/− mice.

(A–C) (Right panels). Representative images of oil red O stained cross-sections of aortic roots of female α_M^−/−/ApoE^−/− and ApoE^−/− mice fed HFD for 3 weeks (A), control chow diet (B), or HFD (C) for 16 weeks. Bar size, 122 µm (Left panels) Lesion area in oil red O-stained aortic roots was quantified as described in Methods. (*P<0.001, n=9 mice/group). (D) (Left panel) Representative images of en face oil red O staining of aortas of α_M^−/−/ApoE^−/− and ApoE^−/− mice fed HFD for 16 weeks. (Right panel) Quantification of atheromatous area (*P<0.001, n=9 mice/group). The data are representative of 3 independent experiments.