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Schematic representation of the dual miR-328 activity in CML-BC. miR-328 decoy activity is essential for the regulation of neutrophil differentiation and its loss determines the blocks of C/EBPα expression and, therefore, the differentiation arrest of myeloid CML-BC blasts. The canonical miR-328 activity controls, at least in part, survival of CML-BC progenitors by regulating the expression of PIM1 serine–threonine kinase.
