Table 1. Summary of hazard ratios, sample sizes and average quality scores from pooled analyses for cell types according to cellular localization.
| General | Tumor | Stroma | ||||
|---|---|---|---|---|---|---|
| DSS | OS | DSS | OS | DSS | OS | |
| Mast cells | NA | 2.23 [0.61–8.11] n468(4) Q4.25 |
NA | 1.21 [0.58–2.51] N630(3) Q5.3 |
1.07 [0.96–1.20] n390(2) Q5 |
1.34 [0.99–1.81] (n291(2) Q6.5 |
| Dendritic cells | NA | 0.65 [0.30–1.38] n525(3) Q4 |
0.80 [0.53–1.20] n390(2) Q5.5 |
0.55 [0.44–0.68] N534(3) Q4.67 |
0.62 [0.47–0.83] n390(2) Q2 |
NA |
| Natural Killer cells | NA | NA | 2.29 [0.61–8.69] n390(2) Q5.5 |
0.45 [0.31–0.65] N374(3) Q2.67 |
0.51 [0.32–0.82] n390(2) Q5 |
NA |
| Macrophages | NA | 2.32 [1.38–3.90] n695(5) Q4.2 |
0.76 [0.50–1.15] n350(2) Q5 |
0.33 [0.17–0.62] N443(4) Q5 |
0.79 [0.59–1.06] n350(2) Q5 |
1.55 [1.01–2.37] n704(5) Q5.4 |
| Macrophages, M1 | NA | NA | NA | 0.10 [0.05–0.21] N140(2) Q4.5 |
NA | 0.63 [0.42–0.94] n140(2) Q4.5 |
| Macrophages, M2 | NA | NA | NA | 0.78 [0.35–1.71] N348(3) Q4.67 |
2.32 [1.66–3.24] n512(2) Q57 |
1.44 [1.06–1.96] n853(5) Q5 |
| T cells, CD3+ | NA | 0.72 [0.53–0.97] n848(4) Q4.5 |
0.64 [0.48–0.86] n350(2) Q52,3 |
0.88 [0.74–1.05] N420(3) Q3 |
1.13 [0.38–3.35] n350(2) Q5 |
0.86 [0.62–1.18] n325(2) Q3 |
| T cells, CD4+ | NA | NA | 0.86 [0.61–1.21] n350(2) Q5.54 |
0.74 [0.48–1.15] N678(4) Q4.5 |
0.23 [0.06–0.95] n350(2) Q5.5 |
0.45 [0.21–0.94] n358(3) Q5.67 |
| T cells, CD8+ | 0.70 [0.48–1.02] n554(3) Q4.341 |
0.80 [0.56–1.15] n1348(6) Q4.5 |
0.69 [0.50–0.96] n350(2) Q5.55,6 |
0.78 [0.66–0.93] N2844(9) Q4.55 |
0.47 [0.36–0.63] n1187(3) Q5.679 |
0.77 [0.69–0.86] n2157(8) Q5 |
| T cells, regulatory | NA | 1.42 [0.78–2.60] n146(2) Q3.5 |
1.43 [0.69–2.94] n578(2) Q47 |
1.00 [0.75–1.34] N578(2) Q4 |
1.80 [1.34–2.43] n678(3) Q47,10 |
1.43 [0.69–2.94] n750(5) Q4.4 |
| B cells | NA | NA | NA | 0.65 [0.42–0.99] N590(2) Q4.5 |
NA | 0.74 [0.56–0.99] n644(2) Q4.5 |
| PD–L1 | NA | NA | 1.67 [1.22–2.29] n2245(10) Q4.87,8 |
1.40 [1.20–1.69] N8970(35) Q5 |
NA | NA |
Results are expressed as pooled HR [95% confidence limit], number of patients (number of studies), Q (average quality score).
DFS = disease-free survival, DSS = disease-specific survival, NA = not analyzable, OS = overall survival, RFS = relapse-free survival.
1DFS, no DSS available.
2RFS HR = 0.73 [0.40–1.32].
3DFS HR = 1.01 [0.54–1.88].
4RFS HR = 1.11 [0.73–1.68].
5DFS HR = 0.58 [0.32–1.04].
6RFS HR = 1.22 [0.82–1.83].
7RFS, no DSS available.
8DFS HR = 1.24 [1.01–1.52].
9DFS HR = 1.69 [1.11–2.55].
10DFS HR = 1.24 [1.01–1.52].