Skip to main content
. 2017 Jul 8;9(37):24653–24671. doi: 10.18632/oncotarget.19065

Figure 8. Collagen 1 increases Kv10.1 and Orai1 expression through ERK1/2 pathway.

Figure 8

(A) Representative western blots showing ERK1/2 phosphorylation in MCF-7 (a) and T-47D (b) cells 48 h post-starvation in presence (+ Coll) and absence (- Coll) of collagen 1. (B-C) Representative western blots showing the effect of PD98059 (40 μM) on ERK1/2 activation, and on Kv10.1 and Orai1 expression in MCF-7 (B) and T-47D (C) cells.Values were normalized as a percentage of the control condition (- Coll). (D-E) Representative western blots showing the effect of Kv10.1 and Orai1 silencing on ERK1/2 phosphorylation in MCF-7 (D) and T-47D (E) cells in collagen 1 conditions. – Coll: without collagen 1, + Coll: with collagen 1.