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. 2018 May 15;9(37):24672–24683. doi: 10.18632/oncotarget.25122

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Copyright: © 2018 Wang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A, B, C) TEM micrographs of the 4^th (A), 10^th (B) and 20^th (C) OH2 generations. The viral particles were observed under a transmission electron microscope after negative staining with phosphotungstic acid. (D) OH2 gene modification (ICP34.5-/ICP47-) for hGM-CSF expression. (E) Flanking sequence of ICP47 in 1^th, 4^th, 10^th and 20^th OH2.