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. Author manuscript; available in PMC: 2018 May 29.
Published in final edited form as: JSM Biochem Mol Biol. 2016 Aug 8;3(1):1014.

Figure 2.

Figure 2

The PS-C4BP complex is essential for inhibiting inflammation. C4BP is a multimer formed by seven alpha chains and one beta chain crosslinked by cysteine disulfide bonds; the C4BP beta chain binds to the sex hormone binding globulin domain (SHBG) of PS. PS-C4BP further binds to the phosphatidylserine in the apoptotic cell membrane and inactivates complements such as C3a and C4a. Streptococcal pyrogenic exotoxin B (SPEB) inactivates the PS-C4BP complex during streptococcal infection. SPEB cleaves PS within the SHBG domain, preventing the PS-C4BP complex from binding the membrane.