Table 2.
Summary of results, statistical analyses, and percent change for average neuron and glia density, glia to neuron ratio, and neuronal soma area in the dorsal (dC) and medial (mC) caudate nucleus, associative putamen (aP), and nucleus accumbens (NA) regions of the striatum in typically developing (TD) individuals and individuals with Williams syndrome (WS).
| dC | mC | aP | NA | ||
|---|---|---|---|---|---|
| Average neuron density | WS | 19,496±1,471 | 22,935±843 | 26,629±2610 | 27,736±2632 |
| TD | 21,061±776 | 24,931±1,210 | 26,509±1,129 | 28,734±3,455 | |
| Average percent change | −6.51% | −6.85% | +2.37% | +6.32% | |
| t-statistics | t=0.9408 df=6.065 |
t=1.354 df=7.144 |
t=0.422 df=5.447 |
t=0.2299 df=7.473 |
|
| P-value | 0.382 | 0.217 | 0.967 | 0.824 | |
| Average glia density | WS | 58,304±3,595 | 65,990±4,266 | 73,106±8,075 | 60,597±4,502 |
| TD | 47,156±2,482 | 55,046±4,213 | 59,100±4,754 | 58,750±7,743 | |
| Average percent change | +25.42% | +22.63% | +28.92% | +12.24% | |
| t-statistics |
t=2.552 df=7.108 |
t=1.826 df=7.999 |
t=1.495 df=6.476 |
t=0.2062 df=6.427 |
|
| P-value | 0.038* | 0.105 | 0.182 | 0.843 | |
| Glia per neuron | WS | 2.92±0.21 | 2.81±0.01 | 2.70±0.19 | 2.23±0.18 |
| TD | 2.24±0.10 | 2.18±0.08 | 2.22±0.12 | 2.03±0.04 | |
| Average percent change | +31.97% | +29.23% | +23.61% | +9.67% | |
| t-statistics |
t=2.947 df=5.647 |
t=4.286 df=6.896 |
t=2.108 df=6.782 |
t=1.094 df=4.443 |
|
| P-value | 0.028* | 0.004** | 0.074 | 0.330 | |
| Average soma area (μm2) | WS | 128±8 | 121±12 | 101±11 | 112±11 |
| TD | 154±4 | 158±8 | 132±11 | 143±12 | |
| Average percent change | −16.62% | −21.76% | −23.27% | −20.14% | |
| t-statistics |
t=2.964 df=5.755 |
t=2.603 df=7.275 |
t=2.029 df=7.952 |
t=1.952 df=7.919 |
|
| P-value | 0.026* | 0.034* | 0.077 | 0.087 | |