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. 2018 May 23;38(5):395–401. doi: 10.3343/alm.2018.38.5.395

Fig. 2. Proposed molecular mechanisms of hematopoietic stem cell (HSC) aging and related disease phenotypes. HSC aging is caused by the alteration of nuclear and mitochondrial genomes, as well as transcriptome and epigenetic changes, resulting in the occurrence of aging-related hematopoietic diseases.

Fig. 2

Abbreviations: mtDNA, mitochondrial DNA; ROS, reactive oxygen species.