Table 4. Within-subject and between-subject biological variation in lipids (%) across studies.
| Analyte | Diurnal biological variation | Long-term biological variation‡ | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Current study* | Chen et al [26] | Sennels et al [27] | Rivera et al [28] | Fraser et al [14] | Minchinela et al [18] | Chen et al [26] | Pineda-Tenor et al [29] | |||||||||
| Mean±SD | CVA (95% CIs) | CVI (95% CIs) | CVG (95% CIs) | CVI | CVG | CVI | CVI | CVI | CVG | CVI | CVG | CVI | CVG | CVI | CVG | |
| TG | 1.38±0.69 | 2.1 (1.8–2.4) | 25 (22.2–28.6) | 35.9 (25.5–47.7) | 32.2 | 54.1 | 37 | 39.1 | 15.3 | 27.8 | 19.9 | 32.7 | 27.6 | 59.3 | 20.3 | 34 |
| TC | 3.99±0.58 | 1.1 (1.0–1.2) | 3.5 (3.0–4.0) | 11.8 (9.3–15.8) | 3.8 | 15.4 | 4.8 | 4.4 | 5.8 | 11 | 5.95 | 15.3 | 7.9 | 13.1 | 6.1 | 15 |
| LDL-C | 2.12±0.61 | 1.1 (1.0–1.2) | 4.4 (3.8–5.0) | 18.7 (14.8–25.0) | 8.2 | 22.8 | 10.4 | 8.6 | / | / | 7.8 | 20.4 | 9.9 | 22.5 | / | / |
| HDL-C | 1.15±0.21 | 1.8 (1.6–2.0) | 3.7 (3.0–4.1) | 15.8 (12.4–21.1) | 12.1 | 18.3 | 2 | 5.3 | / | / | 7.3 | 21.2 | 11.6 | 19.1 | / | / |
| apo-A1 | 1.58±0.22 | 1.7 (1.5–1.9) | 2.3 (1.6–2.4) | 12.8 (10.1–17.1) | 6.7 | 8.6 | / | 4.1 | 6.6 | 13.8 | 6.5 | 13.4 | 6.6 | 10.4 | / | / |
| apo-B | 0.65±0.11 | 3.7 (3.3–4.2) | 2.4† | 14.8 (11.7–19.8) | 7.8 | 26.4 | / | 4.9 | 8.3 | 25.7 | 6.9 | 22.8 | 10.9 | 19.1 | / | / |
*The calculation model for biological variation was based on Braga and Panteghini [13]. Five blood samples were collected from a total of 41 subjects, each sample was tested twice, and a total of 410 samples were acquired. All samples were tested on the same day; †CVI confidence intervals could not be calculated because the CVA was greater than the CVI for apo-B; ‡Fasting blood sample.
Abbreviations: 95% CIs, 95% confidence intervals; TG, triglyceride (mmol/L); TC, total cholesterol (mmol/L); LDL-C, low-density lipoprotein cholesterol (mmol/L); HDL-C, high-density lipoprotein cholesterol (mmol/L); apo-A1, apolipoprotein A1 (g/L); apo-B, apolipoprotein B (g/L); CVA, analytical coefficient of variation; CVI, within-subject biological variation; CVG, between-subject biological variation.